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. 2021 May 3;2(2):e065. doi: 10.1097/AS9.0000000000000065

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 4. — Panel A, Univariate meta-regression showing the effects of the year of publication on the log of the hazard ratio (HR). Compared to the control group, the overall survival (OS) advantage of patients with nonalcoholic fatty liver disease (NAFLD) increased over time (P = 0.02). Each circle represents a study, and the area of each circle is proportional to the relative weight of the respective study. The central line represents the fitted regression line with respective 95% confidence intervals. Panel B, Forest plot for the sensitivity analysis assessing the effects of the year of publication on the OS of NAFLD patients compared to patients with other risk factors. Studies published after 2015 are reported on the upper part of the forest plot while studies published before 2015 are reported on the lower part of the forest plot.