Table 1.

Indications to heart transplantation according to international guidelines. HF: Heart Failure, CPET: Cardiopulmonary Exercise Test, SHFM: Seattle Heart Failure Model, HFSS: Heart Failure Survival Score, GDMT: Guidelines Directed Medical Therapy.

ISHLT	ACC/AHA	ESC
Advanced HF is defined according to CPET parameters and Prognostic HF score. Maximal CPET: VO2 peak ≤ 12 mL/kg/min (≤ 14 if patients intolerant to β-blockers) or VO2 peak < 50% of the predicted value in patients with age < 50 years Submaximal CPET: VE/VCO2 slope ≥ 35 Survival at SHFM: ≤80% Range at HFSS: High risk	Advanced HF despite GDMT	Advanced HF, refractory to medical/device therapy, and without absolute contraindications.