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. 2023 Aug 18;24(16):12930. doi: 10.3390/ijms241612930

Figure 5.

Figure 5

Alpha-mangostin (α-MG) inhibited carvacrol-induced cytokine release in NHEK cells and rescued carvacrol-induced cell death. (A) Alpha-mangostin inhibited the carvacrol-induced release of IL-8 and IL-6 in NHEK. Cells were induced by 300 µM carvacrol with or without either 1 µM alpha-mangostin or 10 µM 74a for 24 h before the ELISA assay. (B) Alpha-mangostin reduced cell death caused by carvacrol in human keratinocytes. Cells were induced by 500 µM carvacrol with or without either 0.3 µM alpha-mangostin or 10 µM 74a for 24 h. The optical density (O.D.) values were normalized to those of the untreated cells. Data are shown as means ± SEM. **** p < 0.0001.