Table 1.
Natural TRPV3 inhibitors.
| Natural Compound | Chemical Structure | Channel Inhibited | IC50 (µM) |
|---|---|---|---|
| Alpha-mangostin |
|
TRPV3 | 0.077 ± 0.013 |
| TRPV1 | 0.43 ± 0.27 | ||
| TRPV4 | 8.470 ± 1.725 | ||
| TRPA1 | 5.092 ± 2.213 | ||
| Citrusinine II [34] |
|
TRPV3 | 12.43 ± 1.86 |
| Coumarin osthole [35,36] |
|
TRPV3 | 37.0 ± 1.9 |
| TRPV1 | Not available | ||
| Isochlorogenic acid A [37] |
|
TRPV3 | 2.7 ± 1.3 |
| Isochlorogenic acid B [37] |
|
TRPV3 | 0.9 ± 0.3 |
| Forsythoside B [38] |
|
TRPV3 | 6.7 ± 0.7 |
| Verbascoside [14] |
|
TRPV3 | 14.1 ± 3.3 |
| Monanchomycalin B [39] |
|
TRPV3 | 3.25 ± 0.6 |
| TRPV1 | 6.02 ± 0.36 | ||
| TRPV2 | 2.84 ± 1.01 | ||
| Pulchranin A [40,41] |
 n = 3 |
TRPV3 | 71.8 ± 9.4 |
| TRPV1 | 27.5 ± 1.4 | ||
| TRPA1 | 174.2 ± 7.4 | ||
| Pulchranin B [40] |
 n = 2 |
TRPV3 | 117.9 ± 11.8 |
| TRPV1 | 95.4 ± 13.1 | ||
| TRPA1 | >200 | ||
| Pulchranin C [40] |
 n = 1 |
TRPV3 | >200 |
| TRPV1 | 182.7 ± 27.0 | ||
| TRPA1 | >200 |