Figure 5.

Examples of dynamic curves demonstrating the phase-dependent duality of the biological action of model RNAs at lower (panels a,c,e,g) and higher dosages (panels b,d,f,h). Cells were cultured 24 h in plate wells of a multimode reader in M9 medium with 0.5% glucose (5% N₂ and CO₂). The dynamics of their growth was characterized by the changes in OD₆₅₀ over two time periods (0–15 and 15–24 h), using the areas under the plots of experimental and control samples. Statistics shown by bar plots are based on at least 3 independent biological trials.