Table 1.
Comprehensive overview of ongoing clinical trials focused on pipeline pharmacological interventions for PTSD as of July 2023.
| Start Date | NCT Number | Status | Study Title | Interventions | Sponsor |
|---|---|---|---|---|---|
| November 2017 | NCT03339258 | Recruiting | A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD | Drug: Doxazosin Mesylate, Extended Release, Drug: Placebo | San Francisco Veterans Affairs Medical Center |
| June 2020 | NCT04448808 | Recruiting | Treating Nightmares in Posttraumatic Stress Disorder with Dronabinol | Drug: BX-1, Drug: Placebo | Charite University, Berlin, Germany |
| May 2021 | NCT04877093 | Recruiting | Repurposing Low-Dose Clonidine for PTSD in Veterans | Drug: Clonidine, Drug: Placebo | Aurora Health Care |
| July 2021 | NCT04951076 | Active, not recruiting | A Phase 2b Study of BNC210 Tablet Formulation in Adults with Post-Traumatic Stress Disorder (PTSD) | Drug: BNC210, Drug: Placebo | Bionomics Limited |
| November 2021 | NCT05103657 | Recruiting | A Study to Test Whether Taking BI 1358894 for 8 Weeks Helps Adults with Post-traumatic Stress Disorder | Drug: BI 1358894, Drug: Placebo | Boehringer Ingelheim |
| January 2022 | NCT05178316 | Recruiting | A Study of JZP150 in Adults with Posttraumatic Stress Disorder | Drug: JZP150, Drug: Placebo | Jazz Pharmaceutical |
| February 2022 | NCT05254405 | Recruiting | An Open Label Pilot Study of IV Brexanolone for the Treatment of Post-Traumatic Stress Disorder | Drug: Brexanolone Injection [Zulresso] | Donald Jeffrey Newport |
| May 2022 | NCT05360953 | Recruiting | Treating Nightmares in Posttraumatic Stress Disorder with Clonidine and Doxazosin | Drug: Clonidine, Drug: Doxazosin, Drug: Placebo | Charite University, Berlin, Germany |
| May 2022 | NCT05391971 | Recruiting | Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder | Drug: Bupivacaine, Drug: Saline | NYU Langone Health |
| June 2022 | NCT05401565 | Recruiting | Study To Evaluate The Efficacy And Safety Of Balovaptan In Adults with Post-Traumatic Stress Disorder (PTSD) | Drug: Balovaptan, Drug: Placebo | Hoffmann-La Roche |
| July 2022 | NCT05446857 | Recruiting | Glecaprevir/Pibrentasvir for the Treatment of PTSD | Drug: Glecaprevir/Pibrentasvir Pill | White River Junction Veterans Affairs Medical Center |
| February 2023 | NCT05741710 | Recruiting | A Study to Assess the Use of Methylone in the Treatment of PTSD | Drug: Methylone, Drug: Placebo | Transcend Therapeutics |