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. 2023 Aug 18;12(16):5376. doi: 10.3390/jcm12165376

Figure 1.

Figure 1

Oteseconazole—mechanism of action [53]. Oteseconazole, similar to triazoles, inhibits the fungal lanosterol 14α-demethylase and, as a result, inhibits ergosterol biosynthesis. Nevertheless, in contrast to triazoles, oteseconazole has not three, but four nitrogen atoms in a five-member ring. This results in greater selectivity for fungal enzymes [53].