Figure 1.
Oteseconazole—mechanism of action [53]. Oteseconazole, similar to triazoles, inhibits the fungal lanosterol 14α-demethylase and, as a result, inhibits ergosterol biosynthesis. Nevertheless, in contrast to triazoles, oteseconazole has not three, but four nitrogen atoms in a five-member ring. This results in greater selectivity for fungal enzymes [53].
