Table 1.

Studies describing new potential medical treatments for uncomplicated VVC.

Author of the Study	Year of Publication	Medical Treatment	Dose	Number of Patients	Time until Symptoms Subside	Side Effects
Stabile G et al. [40]	2021	Unilen® Microbio+	1 tablet containing Saccharomyces cerevisiae in the morning and 1 tablet containing melatonin and GLA-14 in the evening.	40	15 and 30 days	Microscopic wet-mount analysis at 1 and 3 months showed an increase in Lactobacillus count and a reduction in the polymorphonucleate cells in the Unilen® Microbio+ group.
Marrazzo JM et al. [41]	2019	TOL-463	Medication was administered vaginally once nightly for 7 days as either a 5 g dose of gel or a 2 g unit-dose insert.	36 patients with VVC	9–12 days	Headache, vulvovaginal burning sensation, vulvovaginal pruritus.
Mirzaee S et al. [42]	2021	Chlorhexidine	Clotrimazole vaginal cream or 0.5% chlorhexidine vaginal gel was administered.	34 patients with VVC	5 days	Vaginal burning, nausea, vomiting, cutaneous lesions.