Figure 1.

Evaluation of locomotor activity and recognition memory of Tg26 and WT mice. Mice at the age of 12–14 weeks old were used in these experiments. Locomotor activity was assessed using the OF test (A–D); cognition-related recognition memory was evaluated using the NOR test (E,F). (A) The total distances traveled by Tg26 (n = 20) and WT (n = 14) mice in the open field test over a period of 5 min, with male (♂) and female (♀) mice shown. (B) Sex differences between the Tg26 and WT male (left) or female (right) groups. The same groups of mice were used to determine differences in average speed of combined male and female groups (C) or male or female separately (D). The Novel Object Recognition Index/exploratory preference was calculated as described in the Materials and Methods section, with differences between Tg26 and WT mice presented in (E) for the combined sex groups and in subgroups (F). All bar graphs are shown as Mean ± SEM.