Table 1.
Si No | Disease | Findings |
---|---|---|
1 | Multiple Sclerosis | a. Caspase-1 and ASC (apoptosis-associated speck-like protein) in serum are predictors for the severity of the disease [124]. b. IL-1β, Caspase-1 ↑, IL-18, in CSF and PBMC (Peripheral Blood Mononuclear Cells) [125]. |
2 | Alzheimer’s Disease | a. IL-18, Caspase-1, ASC, and IL-1β, in PBMCs. b. IL-1β, IL-18 in astrocytes, microglia, and neurons surrounding Aβ plaques [126,127]. |
3 | Parkinson’s disease | a. Caspase-1, IL-1β in the striatum and serum [128]. |
4 | Neuropsychiatric disorder | a. Increased activity of NLRP3 inflammasome [129,130,131]. |
↑—Increased serum levels.