. 2023 Jul 28;13(8):1648. doi: 10.3390/life13081648

Table 2.

Routine laboratory indicators at 6–10 weeks of gestation between Control group and early-onset PE group.

Variable	Control Group (n = 709)	PE Group (n = 91)	Statistical Magnitude	p Value
Blood cell count
PLT, ×10⁹/L	244 (211–283) ^a	256.5 (226.25–300.5) ^a	−2.58 ^b	<0.001 *
LYM, ×10⁹/L	1.79 (1.48–2.1) ^a	1.98 (1.74–2.40) ^a	−3.56 ^b	<0.001 *
NEU, ×10⁹/L	5.24 (4.28–6.55) ^a	6.25 (5.24–8.35) ^a	−4.63 ^b	<0.001 *
PLT/LYM	135.19 (114.35–163.73) ^a	125.46 (106.26–158.16) ^a	1.51 ^b	0.13
NEU/LYM	2.95 (2.29–3.73) ^a	2.97 (2.42–4.14) ^a	−0.97 ^b	0.33
Index of coagulation function
PT, s	11.3 (11–11.7) ^a	10.9 (10.5–11.3) ^a	5.53 ^b	<0.001 *
PTA, %	91 (88–96) ^a	97 (92–102) ^a	−5.15 ^b	<0.001 *
APTT, s	31.2 (29.3–33.1) ^a	29.6 (27.7–31.3) ^a	4.30 ^b	<0.001 *
TT, s	13.5 (12.9–14) ^a	13.4 (12.7–14) ^a	1.06 ^b	0.29
FIB, g/L	3.27 (2.92–3.66) ^a	3.51 (3.1–3.98) ^a	−3.38 ^b	<0.001 *
D-Dimer, mg/L	0.15 (0.15–0.18) ^a	0.15 (0.15–0.17) ^a	1.13 ^b	0.26
FDP, μg/mL	2.5 (2.5–2.5) ^a	2.5 (2.5–2.5) ^a	−0.79 ^b	0.43
Liver function index
ALT, U/L	13 (10–18) ^a	18 (13–27.5) ^a	−4.67 ^b	<0.001 *
AST, U/L	16 (14–19) ^a	19 (15–25) ^a	−4.70 ^b	<0.001 *
T-Bil, umol/L	12 (10–14.8) ^a	10 (8.9–12.6) ^a	4.71 ^b	<0.001 *
D-Bil, umol/L	1.3 (1–1.8) ^a	1.1 (0.6–1.8) ^a	2.27 ^b	0.02 *
TBA, umol/L	1.6 (1–2.3) ^a	1.4 (1–2.35) ^a	0.54 ^b	0.59
ALP, U/L	49 (43–58) ^a	53 (44–64) ^a	−1.92 ^b	0.05
TP, g/L	72.4 (70.1–74.7) ^a	72 (70.9–74.9) ^a	−0.24 ^b	0.81
ALB, g/L	43.01 ± 2.42 ^c	43.04 ± 3.00 ^c	−0.08 ^d	0.94
GGT, U/L	14 (11–18) ^c	17 (14–28) ^c	−4.86 ^b	<0.001 *
GLB, g/L	29 (27–31) ^c	30 (28–32) ^c	−1.12 ^b	0.26
Renal function index
UREA, mmol/L	3.1 (2.7–3.7) ^a	3.2 (2.8–3.7) ^a	−1.09 ^b	0.28
Cr, umol/L	59 (54–63) ^a	60 (54–65) ^a	−0.87 ^b	0.39
Ca, mmol/L	2.3 (2.24–2.35) ^a	2.33 (2.27–2.4) ^a	−3.40 ^b	<0.001 *
P, mmol/L	1.232 ± 0.136 ^c	1.228 ± 0.138 ^c	0.21 ^d	0.83
UA, umol/L	210 (184–239) ^a	238 (214–279.75) ^a	−5.57 ^b	<0.001 *
Cystatin C, mg/L	0.62 (0.57–0.68) ^a	0.59 (0.54–0.66) ^a	1.18 ^b	0.24
Blood lipid indicators
TCHO, mmol/L	4.01 (3.56–4.48) ^a	4.27 (3.87–4.79) ^a	−3.09 ^b	<0.001 *
TG, mmol/L	1.06 (0.8–1.43) ^a	1.39 (1.15–1.83) ^a	−5.00 ^b	<0.001 *
HDL-C, mmol/L	1.43 (1.24–1.63) ^a	1.33 (1.14–1.58) ^a	1.40 ^b	0.16
LDL-C, mmol/L	2.16 (1.79–2.53) ^a	2.38 (2.11–2.93) ^a	−3.84 ^b	<0.001 *
ApoA₁, g/L	1578 (1355–1893) ^a	1508 (1293–2057) ^a	0.10 ^b	0.92
ApoB, g/L	621 (519–738) ^a	702 (520–828) ^a	−2.35 ^b	0.02 *
Lp(a), mg/L	87 (44–188) ^a	87 (42–188.5) ^a	0.29 ^b	0.77
sdLDL-C, mmol/L	0.7 (0.56–0.87) ^a	0.93 (0.77–1.00) ^a	−3.33 ^b	<0.001 *
Complement/inflammatory markers
CRP, mg/dL	1.04 (0.5–2.6) ^a	1.71 (0.895–3.68) ^a	−2.68 ^b	0.007 *
C1q, mg/L	184 (166–211) ^a	194 (171.75–224.75) ^a	−2.11 ^b	0.03 *

^a Expressed as the median (interquartile range). ^b Rank sum test: Z value; ^c Expressed as mean ± standard deviation (SD); ^d Student’s t-test: t-value; * p-values were statistically different, p < 0.05.