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Summary picture. Depression-like behavior correlated with mGlur5 expression or AD pathologies such as Aβ and tau pathologies. p-ERK causes Aβ deposition, and p-AKT increases pGSK-3B by inhibiting p-tau and increasing it. As a result, it affects depression-like behavior in 6xTg mice, which show increased levels of Aβ and p-tau compared to WT mice.
