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. 2023 Aug 16;12(16):5339. doi: 10.3390/jcm12165339

Table 2.

A comparison of the clinical outcomes of XEN45 after 12 months of follow-up.

Study Type of Study N Preop IOP, mm Hg M12 IOP, mm Hg M12 IOP Lowering Mean Preoperative NOHM Mean NOHM, Last Visit Needling Rates at Last Follow-Up Visit, n (%)
Ozal et al. [37] 1 Retrospective 15 36.1 ± 3.7 * 16.7 ± 3.6 * −19.3 ± 5.0 * 3.6 ± 0.5 * 0.3 ± 0.9 * Not reported
Galal et al. [38] Prospective 13 16.0 ± 4.0 * 12.0 ± 3.0 23 ⁑,† 1.9 ± 1.0 * 0.13 ± 0.11 * 4 (30.7)
Grover et al. [39] Prospective 65 25.1 ± 3.7 * 15.9 ± 5.2 * −9.1 (−10.7 to 7.5) ** 3.5 ± 1.0 * 1.7 † 21 (32.3)
Hengerer et al. [40] Retrospective 242 32.2 ± 9.1 * 14.2 ± 4.0 32.2 ⁑,† 3.1 ± 1.0 * 0.3 ± 0.7 * 67 (27.7) ***
De Gregorio et al. [41] Prospective 33 22.5 ± 3.7 * 13.1 ± 2.4 * −9.4 ± 3.1 * 2.5 ± 0.9 * 0.4 ± 0.8 * Not reported
Mansouri et al. [42] Prospective 149 20.0 ± 7.1 * 13.9 ± 4.3 −31 ⁑,† 1.9 ± 1.3 * 0.5 ± 0.8 * 55 (36.9)
Widder et al. [44] Retrospective 261 24.3 ± 6.6 * 16.8 ± 7.6 * −7.5 ± 7.1 * 2.6 ± 1.1 * 0.2 ± 0.7 * 80 (34)
Reitsamer et al. [45] Prospective 202 21.4 ± 3.6 * 14.9 ± 4.5 * −6.5 ± 5.3 * 2.7 ± 0.9 * 1.1 ± 1.2 * 83 (41.1)
Kalina et al. [47] Prospective 47 22.3 ± 7.3 * 13.4 ± 3.6 * −8.9 ± 5.8 * 3.0 ± 1.2 * 0.8 ± 1.3 * 14 (29.8)
Marcos-Parra et al. [48] Retrospective 65 19.1 ± 5.4 * N.A. −6.7 (−12.9 to −0.5) ** 2.5 ± 0.8 * 0.2 ± 0.6 * 13 (20.0)
Sng et al. [50] Prospective 31 15.6 ± 2.7 * 12.1 ± 2.6 * −3.5 ± 2.7 * 1.4 ± 0.6 * 0.1 ± 0.4 * Not reported
Gabbay et al. [51] Retrospective 151 22.1 ± 6.5 * 15.4 ± 5.9 * −6.7 ± 6.2 * 2.77 ± 1.1 * 0.5 ± 1.0 * 57 (37.7)
Laborda-Guirao et al. [52] Retrospective 80 21.0 ± 5.2 * 14.7 (13.9 to 15.4) ** −6.3 (−8.8 to −4.4) ** 2.8 (2.7 to 3.0) ** 1.1 (0.8 to 1.3) ** 7 (8.8)
Heidinger et al. [53] Retrospective 199 22.8 ± 6.9 * 17.1 ± 5.9 * −5.7 ± 6.6 * 2.9 ± 1.0 * 1.8 ± 1.4 * 44 (22.1)
Ibáñez-Muñoz et al. [54] Retrospective 21 22.3 (21.0−23.5) ** 15.3 (14.3−16.3) ** −7.3 (−9.7 to −5.0) ** 3.0 ± 1.0 * 1.2 ± 1.2 * 19 (26.0)
Karimi et al. [55] Retrospective 259 19.3 ± 6.0 * 14.3 ± 4.4 * −5.1 ± 5.6 * 2.6 ± 0.1 * 1.6 ± 0.5 * 106 (40.9) 2
Laroche et al. [56] Retrospective 20 15.3 ± 6.2 * 12.9 ± 4.5 * −2.4 ± 5.4 * 3.6 ± 0.7 * 1.8 ± 1.5 0 (0.0)
Smith et al. [57] Retrospective 68 22.1 ± 6.4 * 14.8 ± 5.1 * −7.3 ± 5.8 * 2.9 ± 0.8 * 1.1 ± 1.1 * 30 (44.1)
Mansouri et al. [59] Prospective 109 20.0 ± 7.5 * N.A. N.A. 2.0 ± 1.3 * 0.6 ± 0.9 * 58 (45)
Post et al. [61] Prospective 20 21.6 ± 2.3 * 17.7 ± 2.1 * −3.9 ± 2.2 * 3.2 ± 0.8 * 1.6 ± 1.0 * 5 (25.0)
Chao et al. [64] Retrospective 37 21.7 ± 7.7 * 15.0 ± 2.0 * −6.7 ± 5.6 * 3.4 ± 0.9 * 1.3 ± 1.5 * 17 (45.9)
Schargus et al. [66] Retrospective 153 23.9 ± 7.4 * 15.4 ± 5.1 * −8.5 ± 6.4 * 2.6 ± 1.2 * 0.8 ± 1.3 * 64 (35.3)
Theilig et al. [67] Retrospective 100 24.5 ± 6.7 * 16.6  ±  4.8 * N.A. 3.0 ± 1.1 * 1.4  ±  1.5 * 42 (42.0)
Subaşı et al. [69] Retrospective 30 20.4 ± 4.8 * 15.0 ± 1.9 * −6.2 ± 0.9 * 3.1 ± 1.0 * 0.9 ± 1.1 * 13 (43.3)
Fea et al. [70] Prospective 171 23.9 ± 7.6 * 15.5 ± 3.9 * −7.4 ± 7.9 3.0 ± 1.0 * 0.5 ± 1.0 * 79 (46.2)
Rauchegger et al. [71] Retrospective 79 23.4 ± 7.9 * 14.6 ± 3.6 * 31(20−42) ⁑,⁋ 2.7 ± 1.1 * 1.0 ± 1.2 * 37 (62)
Eraslam et al. [81] Retrospective 26 23.9 ± 6.8 * 16.4 ± 2.6 * −7.5 ± 5.2 * 2.9 ± 0.7 0.9 ± 0.9 21 (36.2)
Lewczuk et al. [83] 3 Retrospective 86 25.0 ± 7.5 * 16.8 ± 5.1 * −8.2 ± 6.4 * Not reported Not reported 30 (69.8)
Wanichwecharungruang and Ratprasatporn [84] Retrospective 57 21.6 ± 4.0 15 † −30.6 ⁑,† 2.1 ± 1.4 * 0.5 ± 0.7 * 10 (17.5)
Reitsamer et al. [86] Retrospective 212 20.7 ± 5.1 14.8 † −5.6 † 2.5 ± 1.0 * 0.7 ± 1.0 * 78 (36.8)
Nicolau et al. [89] Retrospective 186 18.1 ± 5.1 * 13.7 ± 5.6 * −4.4 ± 5.3 * 2.5 ± 1.1 * 0.8 ± 1.0 25 (13%)
Monja-Alarcón et al. [95] Retrospective 63 17.6 (0.7) ⁂ 12.6 (0.3) ⁂ 21.9 ± 27.6 ⁑ 2.1 (1.9 to 2.3) ⁋ 0.2 (0.04 to 0.3) ⁋ 19 (30.2)
Buenasmañanas-Maeso et al. [96] Retrospective 63 17.6 ± 5.3 * 12.6 (12.0 to 13.3) ⁋ −21.9 ± 27.4 ⁑ 2.1 (1.9 to 2.3) ⁋ 0.2 (0.04 to 0.3) ⁋ 8 (12.7)
Almendral et al. [99] Retrospective 63 17.6 ± 5.3 * 12.6 ± 2.6 * −22.0 ± 27.5 ⁑ 2.1 ± 0.7 * 0.2 ± 0.5 * 7 (11.1)

† Data about standard deviation was not provided. * Mean (Standard deviation). ** Mean (95% confidence interval). ⁑ Percentage. ⁂ Mean (Standard error). ⁋ 95% Confidence interval. *** All the needling procedures were done between week 1 and month 3. 1 Data calculated from Table 2 of the paper. 2 Postoperative bleb needling or antimetabolite injection. 3 Data from naïve patients. Abbreviations: IOP: intraocular pressure; N: number of eyes; NOHM: number of ocular hypotensive medications.