Table 1.
The genes obtained from data mining and literature review and final combination of the primary gene list for cancer pain management (CPM) strategies.
| Level 1 | Level 2 | Level 3 |
|---|---|---|
| ESR1 | ANGPT1 | ANGPT1 |
| EGFR | ATM | ATM |
| AR | CALCA | CALCA |
| ERBB2 | CCL2 | CCL2 |
| TGFBR2 | CXCL8 | CXCL8 |
| TP53 | CYP2D6, CYP19A1, CYP17A1, CYP27B1 | ESR1 |
| FGFR2 | ESR1 | IL10, IL13, IL2, IL4, IL6, IL1R1, IL1R2 |
| MET | IL2, IL4, IL6, IL10, IL13, IL1R1, IL1R2 | AKT1 |
| FGFR3 | LTA | LTA |
| KIT | NFKBIA | NFKBIA |
| PIK3CA | P2RX7 | P2RX7 |
| AKT1 | P2RY12 | P2RY12 |
| PLAUR | PLAUR | |
| PTGS2 | PTGS2 | |
| RFFL | RFFL | |
| STAT6 | STAT6 | |
| TNF | TNF, TNFRSF11B | |
| TNFRSF11B | VDR | |
| VDR | ARRB2 | |
| ARRB2 | KCNJ3, KCNJ4, KCNJ6, KCNK9, KCNA1, KCND2 | |
| KCNA1, KCND2, KCNJ3, KCNJ4, KCNJ6, KCNK9 | SSTR5 | |
| SSTR5 | ABAT | |
| ABAT | ABCB1 | |
| ABCB1 | BRCA1, BRCA2 | |
| BRCA1, BRCA2 | COMT | |
| COMT | CYP2D6, CYP17A1, CYP19A1, CYP27B1 | |
| FAAH | FAAH | |
| OPRD1, OPRK1, OPRM1 | OPRD1, OPRK1, OPRM1 | |
| UGT2B7 | UGT2B7 | |
| EGFR, FGFR2, FGFR3 | ||
| AR | ||
| ERBB2 | ||
| TGFBR2 | ||
| TP53 | ||
| KIT | ||
| PIK3CA | ||
| MET |
Levels 1, 2, and 3 refer to data mining from GeneCards (from bioinformatics), review literature (from previous investigations), and combination of levels 1 and 2, respectively.