Table 4.

Important information about genes and drugs involved in cancer pain management.

Study	Genes	Drugs/Methods	Ref.
Galvan et al.	SPON1, RHBDF2, ZNF235	Opioids	[45]
Skorpen et al.	OPRM1	Opioids	[42]
Tverdohleb et al.	CYP2D6 expression	Opioids	[90]
Sivanesan and Gitlin	OPRM1	Tramadol and ziconotide	[91]
Obeng et al.	OPRM1, CYP2D6	Morphine, oxycodone, and hydrocodone	[92]
Haji et al.	OPRM1	Morphine	[43]
Mosley et al.	CYP2D6	Oxycodone	[37]
Yang et al.	OPRM1, COMT, CYP2D6, and ILs	Opioid analgesics	[30]
Nissenbaum et al.	CACNG2	-	[93]
Bortsov et al.	CACNG2	Anti-epileptics	[32]
Lee et al.	RFFL/LIG3, ABCC4/MPR4, EGFL6	-	[28]
Genovese and Mao	COMT	Acupuncture	[47]
Xu et al.	OPRM1, OPRK1, OPRD1, SSTR1, SSTR2, and SSTR5	Herbal drugs	[95]
De Bono et al.	BRCA1, BRCA2, ATM	Olaparib	[97]
Bugada et al.	COMT, OPRM1	Opioids	[33]
Rienzo et al.	PRDM12	-	[98]
Reizine et al.	CYP2D6	Codeine, tramadol, hydrocodone	[99]
Saloman et al.	IL1β, IL6, IL2, TNF, MCP1, IL-4, IL-8, CGRP	Pain biomarkers in serum	[100]
Crescioli et al.	IL6, TNF	Opioids	[40]
Satkunananthan et al.	CYP2D6, OPRM1, COMT, ABCB1	Tramadol	[27]
Wang et al.	IL-6, TNF-α	Oxycodone	[109]
Nishizawa et al.	ANGPT1, SLC2A14	Opioid analgesic	[110]
Li et al.	F13B	Sufentanil	[111]

Ref. refers to the references in the main text.