Table 1.
Characterization of GNPs and functionalization parameters: hydrodynamic diameters, polydispersity indices, zeta-potential values, LSPR band positions, drug loading efficiencies, and drug final concentrations.
| HDD (nm) | PDI | Zeta-Potential (mV) | LSPR (nm) | LE (%) | MDS Concentration (µg/mL) | |
|---|---|---|---|---|---|---|
| GNP | 24.94 ± 3.8 | 0.525 | −61.6 ± 1.1 | 518 | - | - |
| GNP-PLU | 44.28 ± 0.29 | 0.716 | −2.35 ± 0.9 | 519 | - | - |
| GNP-MDS-PLU | 122.96 ±13.6 | 0.482 | −0.99 ± 0.2 | 527 | 84.7 | 27.12 |
| GNP-PVP | 73.56 ±6.6 | 0.603 | −5.07 ± 0.6 | 521 | - | - |
| GNP-MDS-PVP | 231.67 ±23 | 0.247 | −5.29 ± 1.6 | 533 | 93.6 | 30.19 |
HDD: hydrodynamic diameter; PDI: polydispersity index; LSPR: localized surface plasmon resonance; LE: loading efficiency; MDS: Midostaurin; GNP: gold nanoparticles; GNP-PLU: Pluronic-coated GNPs; GNP-MDS-PLU: MDS-loaded, PLU-coated GNPs; GNP-PVP: polyvinylpyrrolidone-coated GNPs; GNP-MDS-PVP: MDS-loaded, PVP-coated GNPs.