Table 2.

Histamine receptors in the CNS. Partially based on The Histaminergic System in Neuropsychiatric Disorders, published by Li Cheng, Jiaying Liu and Zhong Chen [37].

Histamine Receptor	Area and Cells	Function	CNS Pathology Involved
H1	Cerebral cortex, thalamus, locus coeruleus, raphe nucleus, astrocytes	Arousal and sleep-wakefulness	Narcolepsy Schizophrenia Alzheimer’s Disease
H2	Cerebral cortex, basal ganglia, hipoccampus, amygdala	Motoric	Schizophrenia Parkinson’s Disease Tourette’s syndrome
H3	All CNS	Regulates the release of other neurotransmitters, such as glutamate, GABA, acetylcholine, and dopamine both in CNS and periphery	Schizophrenia Alzheimer’s Disease Parkinson’s Disease Tourette’s síndrome ADHD
H4	Hematopoietic and immune cells (eosinophils, mast cells, and dendritic cells)	Inflammatory processes