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. Author manuscript; available in PMC: 2023 Aug 25.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Aug 23;189:114505. doi: 10.1016/j.addr.2022.114505

Figure 2.

Figure 2

(Graphical abstract). Mechanism of image guided intra-tumoral immunotherapy and abscopal effect. From left to right, CT or ultrasound are clinically practical ways to inject deep lesions with an immunotherapy controlled release depot that contains a contrast agent for visualization, the resultant treated lesion leads to cytokine release, dendritic cell recruitment and antigen that is picked up by dendritic and macrophage tissues. This material is taken to a draining lymph node where (middle figure) an antigen presenting cell presents to a T – cell to be activated. Right figure, an activated T-cell then subsequently induces apoptosis in distant cancer such as in the lung. Created with BioRender.com.