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. Author manuscript; available in PMC: 2023 Aug 25.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Aug 23;189:114505. doi: 10.1016/j.addr.2022.114505

Figure 5.

Figure 5.

Original figure a-f adapted from Sheth, et. al. JAMA Open, Creative Commons, used with permission. [17] a) Demonstration of injection distribution in a patient throughout the tumor. b-d) Demonstration of injection leaking out of the tumor. e) Injection using a multi-prong injection needle f) contrast demonstrating better injection distribution from the multi-prong injection. g) Side by side comparison of a multi-side hole versus end hole needle injection in a kidney animal model. h) Injection side by side shows more uniform distribution with the multi-side hole. i) Better retention is seen post injection with the multi-side hole. Images in g,h,i reproduced with permission from the work by Munoz et. al. 2021, Creative Commons License. [44]