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. 2023 Aug 25;18(8):e0290428. doi: 10.1371/journal.pone.0290428

Fig 6. Confirmation of select differential gene expression using qPCR.

Fig 6

Select genes were analyzed for differential expression between good and poor responders (relapse before or after 90 days) in each treatment arm using qPCR. CDKN1A was significantly upregulated in good responders in the KPT-9274 arm (p = 0.0149.) TLR3 was upregulated in good responders in the TAK-981 arm, but was not significant (p = 0.2000). AKT3 was upregulated in good responders in the RV1001 arm, and neared significance (p = 0.0802). PIK3CD was upregulated in good responders in the RV1001 arm, and was significant (p = 0.0443). Comparisons were made using unpaired t-tests.