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Nonspecific cholesterol effects on membrane order and structure, irrespective of lipid-chain saturation. A) Area per phospholipid molecule computed for bilayers of POPC, POPC/CHOL, DOPC and DOPC/CHOL. B) Orientational order parameter of lipid molecules, for the same bilayers. C) Degree of entanglement between leaflets, estimated using the number of interdigitating acyl-chain bonds. All data were computed from simulations of bilayers at rest.
