Table 1.

Simulations of all-atom lipid bilayers carried out in this work.

Composition	Conventional MD sampling time (single replica), $\mathit{\mu }$s			Multi-Map enhanced MD sampling time (replica count × time), $\mathit{\mu }$s
POPC	5.3	5.9	3.3	$13\times 0.3$	$12\times 0.6$	$12\times 1.5$
POPC/CHOL	8.9	9.1	3.4	$13\times 0.7$	$14\times 0.7$	$13\times 1.5$
DOPC	2.0	6.5	3.3	$15\times 0.1$	$14\times 0.7$	$13\times 1.5$
DOPC/CHOL	6.2	7.5	3.4	$12\times 0.7$	$15\times 0.6$	$13\times 1.5$
Number of lipids per unit cell	1800	800	200	1800	800	200

The calculations based on enhanced-sampling Multi-Map simulations entailed multiple replicas with increasing degrees of applied curvature, carried out in parallel.