Table 7.
Cenobamate dosing approved according to U.S. Food and Drug Administration protocol a.
| Timing | Amount | |
|---|---|---|
| Initial dosage | Weeks 1 and 2 | 12.5 mg once daily |
| Titration regimen | Weeks 3 and 4 | 25 mg once daily |
| Weeks 5 and 6 | 50 mg once daily | |
| Weeks 7 and 8 | 100 mg once daily | |
| Weeks 9 and 10 | 150 mg once daily | |
| Maintenance regimen | Week 11 and later | 200 mg once daily |
| Incremental doses after 200 mg/day | Every two weeks | Increase 50 mg once daily until 400 mg once daily |
| ||
Observation: Cenobamate maximum dosage recommended is 400 mg once daily. Above cenobamate 250 once daily, there is a significant incidence of side effects. a https://www.xcopri.com (accessed on 30 May 2023).