Fig. 1. Outcomes from the seizure assessment after bilateral overexpression of the transgenes.
AAV1: A latency to 1st motor seizure, B time spent in motor seizures, C latency to status epilepticus (SE). The AAV1-NPY/Y2 vector is highlighted (magenta); AAV2: D latency to 1st motor seizure, E time spent in motor seizures, F latency to SE; AAV8: G latency to 1st motor seizure, H time spent in motor seizures, I latency to SE. Data is shown as mean ± SEM. (n = 7–12 in each group). *P < 0.05 versus same serotype control (EMPTY). One-way ANOVA followed by Bonferroni’s multiple comparison post-hoc tests.