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. 2023 Aug 10;24(9):1540–1551. doi: 10.1038/s41590-023-01588-w

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© The Author(s) 2023, corrected publication 2023

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Fig. 2 — a, Circos plot showing the trans-pQTL ‘hotspot’ at the SH2B3 locus on chromosome 12, associated with six proteins. b, Distribution of the number of identified pQTLs per protein. The HLA was treated as a single region. c,d, Manhattan plots showing genetic associations with plasma abundance of IL-12B (c) and TNFSF10 (TRAIL) (d). The horizontal red line indicates statistical significance (P = 5 × 10⁻¹⁰). Two-sided P values are from meta-analysis of linear regression estimates. The nearest genes in the region of pQTL signals are annotated.