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. 2023 Aug 10;24(9):1540–1551. doi: 10.1038/s41590-023-01588-w

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© The Author(s) 2023, corrected publication 2023

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Fig. 3 — a, Schematic illustrating the cleavage of pro-IL-18 by caspase-1 and subsequent secretion of mature IL-18 from the cell into the extracellular space. b, Regional association plots around NLRC4 showing: the trans-pQTL signal for plasma IL-18 protein (top) from the present study (n = 14,824) and the cis-eQTL signal for NLRC4 (bottom) in whole blood from the eQTLGen study (n = 31,684)¹⁴. The purple diamond shows the sentinel pQTL variant. Other variants are colored by LD to the sentinel pQTL. Two-sided P values are from meta-analysis of linear regression estimates.