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. 2023 Aug 10;24(9):1540–1551. doi: 10.1038/s41590-023-01588-w

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a,b, Unconditioned (a) and conditioned (b) regional association plots at the TNFRSF1A-LTBR locus (rs2364485 ± 100 kb) for multiple sclerosis (top), plasma LTA protein levels (middle) and LTBR mRNA expression in whole blood from eQTLGen¹⁴ (bottom). Multiple sclerosis associations were conditioned on rs1800693 (the strongest disease signal in the region). LTBR mRNA expression levels were conditioned on the following independent eQTLs: rs3759322, rs1800692, rs2228576, rs10849448, rs2364480 and rs12319859. The purple diamond shows the sentinel pQTL variant. Other variants are colored by LD to the sentinel pQTL. Two-sided P values are from meta-analysis of linear regression estimates.