Table 1.
Putative causal protein–disease associations from MR analysis
| Protein | Disease | Odds ratio (95% CI) | P |
| CD40 | Rheumatoid arthritis | 1.28 (1.21–1.37) | 1.4 × 10−15 |
| CD40 | Multiple sclerosis | 0.75 (0.70–0.82) | 1.2 × 10−12 |
| CD40 | Crohn’s disease | 0.81 (0.75–0.87) | 2.2 × 10−8 |
| CD40 | IBD | 0.87 (0.82–0.92) | 1.9 × 10−6 |
| CD5 | Primary sclerosing cholangitis | 0.50 (0.35–0.70) | 8.1 × 10−5 |
| CD6 | IBD | 1.10 (1.06–1.14) | 2.1 × 10−7 |
| CXCL5 | UC | 0.79 (0.72–0.87) | 2.3 × 10−6 |
| IL-12B | IBD | 1.38 (1.31–1.46) | 1.5 × 10−30 |
| IL-12B | UC | 1.38 (1.29–1.48) | 4.7 × 10−20 |
| IL-18R1 | Eczema | 1.15 (1.10–1.20) | 2.1 × 10−10 |
IBD is based on GWASs in which Crohn’s disease and UC cases are grouped together. P is the two-sided P value for the causal estimate of protein on disease from the GSMR package. The odds ratio (OR) is associated with a 1 s.d. increase in the protein level. OR > 1 indicates that genetic propensity to higher levels of the plasma protein is associated with higher disease risk and OR < 1 with reduced risk. CI, confidence interval.