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Correlation of the replication competence of the amplified HBV genomes with HBsAg and HBeAg levels and the number of PCR-introduced mutations
| Replication competence | No. of genomes (%) expressing:
|
PCR-introduced mutations
|
|||
|---|---|---|---|---|---|
| HBsAg | HBeAg | HBsAg and HBeAg | Errors/kb sequenced (%) | Errors/genome (avg) | |
| Authentic (n = 8) | 8 (100) | 8 (100) | 8 (100) | 4/13.7 (0.029) | 0.9 |
| Defective (n = 17) | 15 (88) | 10 (59) | 8 (47) | 28/16.6 (0.169) | 5.4 |
