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. 2023 Jul 14;37(9):1767–1778. doi: 10.1038/s41375-023-01968-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — BPDCN involving the skin of a 14-year-old female. Staining with hematoxylin and eosin reveals a diffuse monotonous dermal-based infiltrate of medium-sized blastoid cells that spares the Grenz zone and epidermis and focally extends into the subcutaneous tissue (A, ×2; B, ×200). Occasional mitotic figures are present (C, ×500). Tumor cells are positive for CD4, CD56, and CD123 but negative for CD3, CD19, and myeloperoxidase (not shown). BPDCN involving the BM of a 16-year-old male. Staining with hematoxylin and eosin reveals an interstitial and diffuse infiltrate displacing hematopoietic elements (D, ×200;). A Wright-Giemsa–stained BM smear shows numerous blastic cells with irregular nuclear contours, immature chromatin, occasional small nucleoli, and variable light basophilic cytoplasm with occasional tail-like protrusions (E, ×1000). By immunohistochemistry, tumor cells are positive for TCF4/CD123 (F, ×500) and CD56 (G, ×500) but negative for CD3, CD19, and myeloperoxidase (not shown).