Table 1.
Comparison of key characteristics in presentation and outcome between adult and pediatric patients with BPDCN.
| Characteristic | Adult patients [123] | Pediatric and Adolescent Patients | |
|---|---|---|---|
| Age (Years) | Median | 66 | 10 |
| Range | 19–86 | 0.6–18 | |
| Sex (M:F) | 4:1 | 1:1 | |
| Presentation | Skin+ Only | 35% | 25% |
| BM+ | 64% | 75% | |
| CNS+ During Therapy | 33% | 60% | |
| Dead of Disease – Initial Therapy | 66% | 7% | |
| HSCT at CR1 | 33% | 20% | |
| Overall Survival (Months) | Median | 23 | - |
| Mean | - | 78.8 | |
| Range | 0.9–158 | 1–132 | |
Summary statistics of adult patients from Pemmaraju et al. (2022).
BM bone marrow disease, CNS central nervous system disease, HSCT hematopoietic stem cell transplant, CR1 relapse from first successful therapy.