Fig. 1.

Flow chart depicting the subcutaneous dosing regimen of HsTX1[R14A] (1 mg/kg) or vehicle in SAMP8 mice and the subsequent behavioral assessment and end point studies. The behavioral assessments were spread across the last 4 weeks of treatment to ensure animal welfare and to prevent stress-induced behavioral changes from intensive testing in a short period. End point experiments were performed immediately after the 2-month treatment