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. 2023 May 24;20(4):1198–1214. doi: 10.1007/s13311-023-01387-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The NOR performance of SAMP8 mice that were administered subcutaneous HsTX1[R14A] (1 mg/kg) or PBS every-other-day, showing A the distance travelled by mice in the open arena over 10 min in the two habituation sessions on day 1 and day 2, B the % of time that mice spent in the centre zone during the day 1 habituation, and C the discrimination index of mice for object exploration in the NOR testing session. Data are presented as mean ± SEM (n = 5–6 mice per group), with *p < 0.05, and ***p < 0.001 (Two-way ANOVA)