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. 2023 May 24;20(4):1198–1214. doi: 10.1007/s13311-023-01387-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — GSEA enrichment plots for hallmark gene sets, showing the upregulated gene sets A Hedgehog signaling, B Wnt/beta-catenin signaling, C apical junction, D notch signaling, and the downregulated gene sets E oxidative phosphorylation, F interferon alpha response, G interferon gamma response, H reactive oxygen species pathway, in brains from 6-month-old SAMP8 mice that had been treated with HsTX1[R14A] (n = 9–12 mice per genotype)