Fig. 7.

FA improves the decrease in p-Y1472 GluN2B by decreasing STEP in APP/PS1 mice. A The expression levels of GluN1, GluN2A, GluN2B, and p-Y1472 in hippocampal lysates from C57 control and APP/PS1 mice with or without long-term FA treatment were evaluated by western blotting. B–E The statistical analysis of western blot bands from A. F The expression levels of STEP, np-S221, Fyn, and p-Y416 in hippocampal lysates of C57 control and APP/PS1 mice with or without long-term FA treatment were evaluated by western blotting. G–J Statistical analysis of western blot bands from F. β-Actin served as the loading control (n = 6). The data are presented as the mean ± SEM. ***p < 0.001 and ****p < 0.0001 vs. control or vs. APP/PS1 mice groups. p-Y1472, phosphorylated GluN2B at Tyr1472; np-S221, nonphosphorylated STEP at Ser221; p-Y416, phosphorylated Fyn at Tyr416