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. 2023 Apr 20;20(4):1081–1108. doi: 10.1007/s13311-023-01356-6

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© The American Society for Experimental Neurotherapeutics, Inc. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 8 — FA downregulates STEP by modulating the calcium-related PP2B/DARPP-32/PP1 axis in APP/PS1 mice. A The expression levels of DARPP-32, p-T34, PP1, and p-T320 in hippocampal lysates from C57 control and APP/PS1 mice with or without long-term FA treatment were evaluated by western blotting. B–E Statistical analysis of western blot bands from A. β-Actin served as the loading control (n = 6). F Statistical analysis of the PP2B activity test using the PP2B activity kit (n = 6). The data are presented as the mean ± SEM. ***p < 0.001 and ****p < 0.0001 vs. control or vs. APP/PS1 mice groups. p-T34, phosphorylated DARPP-32 at Thr34; p-T320, phosphorylated PP1 at Thr320