Table 3.
SOCS3 methylation–height association in replication cohorts
| Cohort | n | CpG ID | Effect sizea | 95% CI | P value | Country (ethnicity) |
|---|---|---|---|---|---|---|
| MPC | 553 | cg11047325 | 0.20 | 0.15, 0.25 | 2.8E−14 | India (SAS) |
| cg13343932 | 0.21 | 0.16, 0.26 | 1.5E-13 | |||
| cg18181703 | 0.29 | 0.21, 0.37 | 5.3E-12 | |||
| PMMST | 284 | cg11047325 | 0.02 | 0.00, 0.04 | 4.7E-02 | Gambia (AFR) |
| cg13343932 | 0.02 | 0.00, 0.04 | 4.4E-02 | |||
| cg18181703 | 0.04 | 0.00, 0.07 | 3.2E-02 | |||
| ENID (6 years) | 142 | cg11047325 | 0.06 | 0.03, 0.10 | 1.4E-04 | Gambia (AFR) |
| cg13343932 | 0.08 | 0.04, 0.11 | 8.1E-05 | |||
| cg18181703 | 0.11 | 0.06, 0.16 | 2.3E-05 | |||
| ENID (2 years)b | 238 | cg18181703 | 0.14 | 0.06, 0.22 | 1.0E-03 | Gambia (AFR) |
| ALSPACb | 863 | cg18181703 | 0.11 | 0.04, 0.18 | 2.2E-03 | United Kingdom (EUR) |
MPC Mysore Parthenon Cohort, PMMST Periconceptional Multiple Micronutrients Supplementation Trial, ENID Early Nutrition and Immune Development, ALSPAC Avon Longitudinal Study of Parents and Children, n sample size, CI confidence interval, SAS South Asians, AFR Africans, EUR Europeans, CpG ID CpG probe on the EPIC Infinium BeadChip Array.
Multiple linear regression models with predefined covariates were used for replication analyses (see “Methods”).
aEffect size indicates change in height in centimetres associated with a 1% increase in CpG methylation.
bMethylation measures available from Illumina Infinium methylation 450 K array which covers only cg18181703. P value: statistical significance.