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. 2023 Aug 25;14(8):556. doi: 10.1038/s41419-023-06072-9

Fig. 6. LZTR1 loss promotes tumor metastasis in a metastatic xenograft model.

Fig. 6

A, B A549 cell lines were tail vein injected into female BALB/c-nude mice. The level of metastasis to the lungs was assessed at (A) 8 or (B) 12 weeks after injection (n = 4–7). The collected lungs were stained with hematoxylin and eosin stain (HE). Arrowheads indicate representative metastatic nodules. Values are the mean ± SEM; **P ≤ 0.01 (Wilcoxon-Mann-Whitney test). C The collected lungs were stained with Masson’s trichrome stain (MT), anti-COL1A1 antibody, anti-α-SMA antibody, anti-ZEB1 antibody, anti-SNAIL + SLUG antibody, and anti-human specific Lamin-B1 antibody.