Table 2.
Completed clinical studies on miRNAs (based on ClinicalTrials.gov (accessed on 30 November 2022))
| No | NCT no | Study title | Cancer | Location | Participants (Active/original) |
|---|---|---|---|---|---|
| NCT03452514 |
Addition of microRNA Blood Test to Lung Cancer Screening Low Dose CT |
Lung cancer |
Massachusetts General Hospital, Boston, Massachusetts, USA Brigham and Women’s Hospital, Boston, Massachusetts, USA Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA Lahey Hospital & Medical Center, Burlington, Massachusetts, USA |
479/479 | |
| NCT02445924 | MicroRNA Genetic Signature in NSCLC Egyptian Patients | Non-small cell lung cancer | Chest Department, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt | 40/40 | |
| NCT03293433 | Quantification of microRNAs in Diagnosis of Pulmonary Nodule | Pulmonary cancer |
University Hospital of la Réunion, France University Hospital of Toulouse, Toulouse, France |
103/103 | |
| 4 | NCT03741829 | TS Overexpression in SCLC: Mechanism and Therapeutic Targeting | Small cell lung cancer | Wake Forest University Health Sciences Wilson-Salem, North Carolina, USA | 12/12 |
| 5 | NCT00897234 | Blood Samples From Patients From Patients With Non-Small Cell Lung Cancer and From Healthy Volunteers | Lung cancer |
Masonic Cancer Center at University of Minnesota, Minneapolis, Minnesota USA |
84/84 |
| 6 | NCT00864266 | Biological Factors Predicting Response to Chemotherapy in Advanced Non Small Cell Lung Cancer | Non-small cell lung cancer |
Department of Pneumology Clinique Saint-Luc, Bouge, Belgium Department of Intensive Care Unit and Thoracic Oncology Institut Jules Bordet, Brussels, Belgium Service de Pneumologie Hôpital Erasme, Brussels, Belgium Department of Pneumology Hôpital Saint-Joseph, Gilly, Belgium Hôpital Ambroise Paré, Mons, Belgium Department of Pneumology Centre Hospitalier de Mouscron, Mouscron, Belgium |
70/70 |
| 7 | NCT02837809 | Early Lung Cancer Detection in High Risk Individuals | Lung cancer | Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy | 4099/4099 |
| 8 | NCT00840125 | Study of Erlotinib With Docetaxel in Selected Non Small Cell Lung Cancer Patients in First Line Treatment | Non-small cell lung cancer | Meir Medical Center, Kfar Saba, Israel | 4/40 |
| 9 | NCT02369198 | MesomiR 1: A Phase I Study of TargomiRs as 2nd or 3rd Line Treatment for Patients With Recurrent MPM and NSCLC |
Malignant pleural mesothelioma Non-small cell lung cancer |
Concord Repatriation General Hospital, Sydney, New South Wales, Australia Chris O'Brien Lifehouse, Sydney, New South Wales, Australia Northern Cancer Institute, Sydney, New South Wales, Australia |
27/30 |
| 10 | NCT00926640 | A Phase I Study of Belinostat in Combination With Cisplatin and Etoposide in Adults With Small Cell Lung Carcinoma and Other Advanced Cancers |
Carcinoma neuroendocrine Small cell lung cancer carcinoma Malignant epithelial neoplasms |
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, USA | 28/44 |
| 11 | NCT01779388 | Bronchoscopy Assisted by Electromagnetic Navigation (EMN) in the Diagnosis of Small Pulmonary Nodules | Pulmonary nodule Cm | Institut Jules Bordet, Brussels, Belgium | 120/120 |
| 12 | NCT02387307 | A Study of rSIFN-co in Subjects With Advanced Solid Tumors |
Carcinoma, non-small-cell lung Carcinoma, Renal cell Melanoma Carcinoma, hepatocellular Colon cancer |
National Cancer Centre Singapore, Singapore | 42/42 |
| 13 | NCT02169271 | Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung | Multiple pulmonary nodules |
M D Anderson Cancer Center, Houston, Texas, USA European Institute of Oncology, Milano, Italy |
109/128 |
| 14 | NCT02194231 | ATREUS—Phase II Study on the Activity of Trabectedin in Patients With Malignant Pleural Mesothelioma (MPM) | Malignant pleural mesothelioma |
Azienda ospedaliera ss. Antonio e Biagio e Cesare Arrigo, Alessandria, AL, Italy Cliniche Humanitas Gavazzeni, Bergamo, BG, Italy Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi, Bologna, Bo, Italy P.O. Spedalli Civili, Brescia, BS, Italy Azienda Ospedaliera S. Gerardo di Monza, Monza, MB, Italy Istituto Clinico Humanitas, Rozzano, MI, Italy •Istituto Oncologico Veneto—IOV, Padova, PD, Italy •Azienda Ospedaliro-Universitaria di Parma, Parma, Italy |
145/145 |