Table 3.
Ongoing clinical studies on miRNAs (based on ClinicalTrials.gov (accessed on 30 November 2022))
| No | NCT no | Study title | Cancer | Location | Participants (Estimated) |
|---|---|---|---|---|---|
| 1 | NCT02247453 | Plasma microRNA Profiling as First Line Screening Test for Lung Cancer Detection: a Prospective Study | Lung cancer | Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy | 4119 |
| 2 | NCT03074175 | Plasma miRNAs Predict Radiosensitivity of Different Fractionation Regimes in Palliative Radiotherapy for Advanced Non-small Cell Lung Cancer Multicenter Controlled Study. (RadimiR-01) | Advanced NSCLC | Xinqiao Hospital of Chongqing, Chongqing, China | 240 |
| 3 | NCT04427475 | Prediction of Immunotherapeutic Effect of Advanced Non-small Cell Lung Cancer | NSCLC | Cancer Hospital Fudan University Shanhai, Shanghai, China | 200 |
| 4 | NCT01240369 | Association Between VEGF-C and miRNA Clinical Non-small Cell Lung Cancer and Esophagus Squamous Cell Carcinoma | NSCLC, ESCC | 250 | |
| 5 | NCT04323579 | Validation of Multiparametric Models and Circulating and Imaging Biomarkers to Improve Lung Cancer EARLY Detection | Lung cancer | Istituto Clinico Humanitas, Rozzano, Milano, Italy | 2000 |
| 6 | NCT04629079 | Improving the Early Detection of Lung Cancer by Combining Exosomal Analysis of Hypoxia With Standard of Care Imaging | Lung cancer | Borthwick Research Unit, Lister Hospital, Stevenage, UK | 800 |
| 7 | NCT03397355 | Monitoring the Changes of Tumor-related Biomarkers Before and After Pulmonary Nodule Biopsy | Lung cancer | China-Japan Friendship Hospital, Beijing, Beijing, China | 1000 |
| 8 | NCT04965129 | Biopsy Supplementation of n-3 PUFA in the Modulation of Lean Mass in Patients With Lung Cancer Receiving a High-protein Diet | Lung cancer | Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil | 50 |
| 9 | NCT02301858 | Identification of Predictive and Prognostic Markers for Lung Cancer With Metastases | Metastatic lung cancer | Vestfold Hospital Trust, Tønsberg, Norway | 100 |
| 10 | NCT04315766 | Optimised Lung Cancer Screening to Prevent Cardiovascular and Pulmonary Diseases Coupled With Primary Prevention | Lung cancer | Istituto Clinico Humanitas, Rozzano, Milano, Italy | 2000 |
| 11 | NCT03233724 | Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for, Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas | Advanced or metastatic non-small cell lung cancers and esophageal carcinomas | National Institutes of Health Clinical Center, Bethesda, Maryland, USA | 85 |
| 12 | NCT03721120 | Evaluation of the Feasibility and Clinical Relevance of Liquid Biopsy in Patients With Suspicious Metastatic Lung Cancer | Metastatic lung cancer |
Centre Hospitalier de Bayeux, Bayeux, France Hopital Louis Pradel, Bron, France Centre François Baclesse, Caen, France Centre Maurice Tubiana, Caen, France Infirmerie Protestante, Caluire et Cuire, France Centre Hospitalier Public du Cotentin, Cherbourg, France CH Les Oudairies, La Roche-sur-Yon, France Hôpital Privé Jean Mermoz, Lyon, France Centre Leon Berard, Lyon, France Groupe Hospitalier de la région de Mulhouse et Sud-Alsace, Mulhouse, France Centre Hospitalier de Bayeux, Bayeux, France Hopital Louis Pradel, Bron, France Centre François Baclesse, Caen, France Centre Maurice Tubiana, Caen, France Infirmerie Protestante, Caluire et Cuire, France Centre Hospitalier Public du Cotentin, Cherbourg, France CH Les Oudairies, La Roche-sur-Yon, France •Hôpital Privé Jean Mermoz, Lyon, France •Centre Leon Berard, Lyon, France Groupe Hospitalier de la région de Mulhouse et Sud-Alsace, Mulhouse, France and 6 more |
286 |
| 13 | NCT02511288 | Liquid Biopsies in Patients Presenting Non-small Cell Lung Cancer | Non-small cell lung |
Centre Hospitalier Annecy Genevois, Annecy, France CH Fleyriat, Bourg-en-Bresse, France Hôpital Louis Pradel, Bron, France CHU Grenoble Alpes, Grenoble, France Centre Léon Bérard, Lyon, France CHRU de Saint-Etienne, Saint-Priest-en-Jarez, France Institut de Cancérologie Lucien Neuwirth, Saint-Priest-en-Jarez, France Hôpital Nord Ouest, Villefranche-sur-Saône, France |
900 |
| 14 | NCT03824327 | Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases | Lung non-small cell carcinoma | Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States | 24 |
| 15 | NCT04515004 | Leucoselect Phytosome for Neoadjuvant Treatment of Early Stage Lung Cancer | Early-stage lung cancer (I and II) | New Mexico VA Health Care System, Albuquerque, NM, Albuquerque, New Mexico, United States | 30 |
| 16 | NCT01560195 | A Study of Pegylated rhG-CSF as Support to Advanced Non-Small-Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy | NSCLC | Shanghai Pulmonary Hospital, Shanghai, Shanghai, China | 150 |
| 17 | NCT05136846 | Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer | Locally advanced lung non-small cell carcinoma | Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA | 28 |
| 18 | NCT04392505 | Durvalumab(MEDI4736) After chemoRadioTherapy(DART) for NSCLC-a Translational and Biomarker Study | Non-small cell carcinoma stage III |
North Estonia Medical Centre, Tallinn, Estonia Oulu University Hospital, Oulu, Finland Tampere University Hospital, Tampere, Finland Turku University Hospital, Turku, Finland National Cancer Institute, Vilnius, Lithuania Haukeland universitetssykehus, Bergen, Norway Oslo University Hospital, Oslo, Norway Stavanger University Hospital, Stavanger, Norway Universitetssykehuset i Nord-Norge, Tromsø, Norway St. Olavs Hospital, Trondheim, Norway |
100 |
| 19 | NCT01629498 | Image-Guided, Intensity-Modulated Photon or Proton Beam Radiation Therapy in Treating Patients With Stage II-IIIB Non-small Cell Lung Cancer | Non-small cell carcinoma stages II–III | M D Anderson Cancer Center, Houston, Texas, USA | 100 |
| 20 | NCT05311709 | Sotorasib in Advanced KRASG12C-mutated Non-small Cell Lung Cancer Patients With Comorbidities | Non-small cell carcinoma stages III–IV | Vestre Viken Health Trust, Drammen, Viken, Norway | 100 |
| 21 | NCT03108677 | Circulating Exosome RNA in Lung Metastases of Primary High-Grade Osteosarcoma |
Lung metastases Osteosarcoma |
Ruijin Hospital Shanghai Jiao Tong University School of medicine, Shanghai, Shanghai, China | 40 |
| 22 | NCT05000710 | Concomitant Radiotherapy, Tremelimumab & Durvalumab for Advanced NSCLC Patients Progressing on First-line Immunotherapy | Metastatic or locally advanced NSCLC | Sheba Medical Centre, Ramat Gan, Israel | 29 |