FIG. 2.
Cerebral physiological responses to ICP-lowering therapeutics. (A) Association between ICP and EtCO2. (B) ICP, MAP, and CPP responses to a bolus dose of hypertonic saline. (C) ICP, MAP, CPP, and BIS left/right responses to a bolus dose of sedation. a.u., arbitrary units; BIS, bispectral index; CPP, cerebral perfusion pressure; EtCO2, end-tidal carbon dioxide; ICP, intracranial pressure; MAP, mean arterial pressure. Data from Winnipeg Acute TBI Laboratory Database, with full ethics approval in place for access, processing, and publication (H2017:181, H2017:188, H2020:118).