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. 2023 Aug 7;4(1):478–494. doi: 10.1089/neur.2023.0031

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© Kevin Y. Stein et al., 2023; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 3. — Patient example of iICP generation. LOESS function plot with 95% confidence intervals, intersection with PRx of +0.20 (dotted line) determines the patient's personalized threshold. a.u., arbitrary units; iICP, individualized intracranial pressure threshold; LOESS, locally estimated scatterplot smoothing; PRx, pressure reactivity index. Data from Winnipeg Acute TBI Laboratory Database, with full ethics approval in place for access, processing, and publication (H2017:181, H2017:188, H2020:118).