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. 2023 Aug 16;34(15-16):682–696. doi: 10.1089/hum.2022.211

Figure 3.

Figure 3.

AAV-PR transduces aortic smooth muscle cells as well as multiple peripheral tissues. Ai9 mice were left untreated (noninjected) or were injected with AAV-PR-CBA-Cre and 5 weeks later, intrinsic tdTomato fluorescence observed. (A) Intrinsic tdTomato fluorescence (magenta) was readily detected in aorta of injected but not in untreated mice. Scale bar = 30 μm (B). Many of the transduced cells in aorta were smooth muscle cells as they colocalized with α-SMA and SM22α. Scale bar = 30 μm (C). Cell lining the coronary artery were transduced by AAV-PR. Scale bar = 100 μm (D). tdTomato expression in peripheral tissues of Ai9 mice injected with AAV-PR-CBA-Cre injected (left panels) and noninjected (right panels). Scale bars are as follows: liver, kidney = 500 μm; lungs, bladder, small intestine = 200 μm; large intestine = 100 μm.