Table 2. Multivariate Analysis of Clinical and Pathological Factors Associated With OS and DFS in Patients With IDC.
| Factor | OS | DFS | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| Age | 1.026 (1.020-1.032) | <.001 | 1.002 (0.997-1.007) | .49 |
| BCS vs mastectomy | 0.80 (0.64-1.00) | .047 | 1.02 (0.87-1.20) | .81 |
| Concurrent DCIS | 1.00 (0.86-1.12) | .76 | 0.99 (0.89-1.10) | .81 |
| Invasive size | 1.28 (1.23-1.34) | <.001 | 1.26 (1.21-1.30) | <.001 |
| Grade 2 vs 1 | 1.89 (1.22-2.94) | .005 | 3.00 (1.99-4.52) | <.001 |
| Grade 3 vs 1 | 2.26 (1.43-3.58) | <.001 | 3.17 (2.07-4.83) | <.001 |
| LVI | 1.33 (1.15-1.54) | <.001 | 1.36 (1.20-1.53) | <.001 |
| NI | 1.07 (0.86-1.33) | .54 | 1.05 (0.87-1.27) | .59 |
| No. of LNMs | 1.051 (1.045-1.058) | <.001 | 1.047 (1.042-1.053) | <.001 |
| DM | 4.31 (2.92-6.37) | <.001 | NA | NA |
| Ki67 | 1.69 (1.21-2.36) | .002 | 1.16 (0.87-1.56) | .31 |
| HR positive vs negative | 0.66 (0.57-0.77) | <.001 | 0.82 (0.72-0.94) | .003 |
| ERBB2 positive vs negative | 0.88 (0.76-1.01) | .07 | 0.88 (0.78-0.99) | .03 |
Abbreviations: BCS, breast-conserving surgery; DCIS, ductal carcinoma in situ; DFS, disease-free survival; DM, distant metastasis; HR, hormone receptor; IDC, invasive ductal carcinoma; LVI, lymphovascular invasion; LNM, lymph node metastases; NA, not applicable; NI, nerve invasion; OS, overall survival.