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. 2023 Aug 25;6(8):e2329729. doi: 10.1001/jamanetworkopen.2023.29729

Table 2. Performance Metrics for Classification of Admission (All Sepsis vs Nonsepsis).

All sepsis classification (n = 1663) Performance metric (95% CI)
Accuracy Sensitivity Specificity False negativea False positiveb Balanced accuracyc Diagnostic odds ratiod
PSS ≥5 0.54 (0.54-0.55) 0.95 (0.93-0.96) 0.53 (0.53-0.54) 0.05 (0.04-0.07) 0.47 (0.46-0.47) 0.74 (0.73-0.74) 19.82 (16.01-24.52)
PSS ≥6 0.63 (0.62-0.63) 0.92 (0.91-0.93) 0.62 (0.61-0.62) 0.08 (0.07-0.09) 0.38 (0.38-0.39) 0.77 (0.76-0.78) 18.63 (15.59-22.26)
PSS ≥7 0.69 (0.69-0.69) 0.89 (0.87-0.90) 0.68 (0.68-0.69) 0.11 (0.10-0.13) 0.32 (0.31-0.32) 0.79 (0.78-0.79) 17.44 (14.94-20.34)
PSS ≥8 0.74 (0.73-0.74) 0.85 (0.83-0.87) 0.73 (0.73-0.74) 0.15 (0.13-0.17) 0.27 (0.26-0.27) 0.79 (0.78-0.80) 15.96 (13.92-18.30)
PSS ≥9 0.78 (0.77-0.78) 0.82 (0.80-0.84) 0.77 (0.77-0.78) 0.18 (0.16-0.20) 0.23 (0.22-0.23) 0.80 (0.79-0.81) 15.78 (13.90-17.91)
PSS ≥10 0.81 (0.80-0.81) 0.78 (0.76-0.80) 0.81 (0.80-0.81) 0.22 (0.20-0.24) 0.19 (0.19-0.20) 0.80 (0.79-0.81) 15.10 (13.41-16.99)
SIRS 0.43 (0.43-0.44) 0.95 (0.94-0.96) 0.42 (0.41-0.42) 0.05 (0.04-0.06) 0.58 (0.58-0.59) 0.68 (0.68-0.69) 13.49 (10.82-16.81)
qSOFA 0.70 (0.69-0.70) 0.83 (0.81-0.85) 0.69 (0.69-0.70) 0.17 (0.15-0.19) 0.31 (0.30-0.31) 0.76 (0.75-0.77) 11.08 (9.73-12.61)
SOFA 0.45 (0.44-0.45) 0.97 (0.97-0.98) 0.43 (0.43-0.44) 0.03 (0.02-0.03) 0.57 (0.56-0.57) 0.70 (0.70-0.71) 28.60 (21.12-38.73)

Abbreviations: PSS, Predicting Sepsis Score; qSOFA, quick Sepsis-Related Organ Failure Assessment; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment.

a

False negative indicates the proportion of missed true sepsis cases.

b

False positive indicates the proportion of nonsepsis cases falsely classified as sepsis.

c

Balanced accuracy is calculated as sensitivity plus specificity divided by 2.

d

Diagnostic odds ratio is calculated as the positive likelihood ratio divided by the negative likelihood ratio.