Table 2.
Summary of GENCOV participant self-reported health conditions, stratified by hospitalization status. p-values, crude odds ratios (ORs), adjusted odds ratios (aORs), and 95% confidence intervals were calculated from the logistic regression models. Variables which were controlled in the multiple logistic regression model included continuous age and BMI, sex, ethnicity (White/European vs. non-White/European), hypertension, diabetes, cardiovascular conditions, and pulmonary conditions. Percentages may not add up to 100% due to rounding.
| No. of Observations (%) | |||||||
|---|---|---|---|---|---|---|---|
| Univariable | Multivariable | ||||||
| Health Condition | Inpatient (n = 54) |
Outpatient (n = 912) |
Total (n = 966) |
p (OR) | OR [95%CI] | p (aOR) | aOR [95%CI] |
| Hypertension | |||||||
| Yes | 22 (40.7) | 101 (11.1) | 123 (12.7) | <0.001 |
6.56
[3.58–12.01] |
0.015 |
2.78
[1.22–6.34] |
| No | 26 (48.1) | 783 (85.9) | 809 (83.7) | ||||
| Unknown | 6 (11.1) | 28 (3.1) | 34 (3.5) | ||||
| Endocrine Conditions | |||||||
| Yes | 17 (31.5) | 100 (11.0) | 117 (12.1) | <0.001 |
4.20
[2.25–7.83] |
0.343 | 1.91 [0.50–7.32] |
| Diabetes (Any) | 13 (24.1) | 48 (5.3) | 61 (6.3) | <0.001 |
6.37
[3.17–12.80] |
0.677 | 0.79 [0.26–2.41] |
| Type 2 Diabetes | 13 (24.1) | 45 (4.9) | 58 (6.0) | ||||
| Type 1 Diabetes | 1 (1.9) | 5 (0.5) | 6 (0.6) | ||||
| Endocrine Cancer | 1 (1.9) | 5 (0.5) | 6 (0.6) | ||||
| Endocrine Autoimmune Disorders | 0 (0.0) | 10 (1.1) | 10 (1.0) | ||||
| Gestational Diabetes | 0 (0.0) | 2 (0.2) | 2 (0.2) | ||||
| Maturity-Onset Diabetes of the Young | 0 (0.0) | 2 (0.2) | 2 (0.2) | ||||
| Pre-Diabetes | 0 (0.0) | 2 (0.2) | 2 (0.2) | ||||
| No | 32 (59.3) | 790 (86.6) | 822 (85.1) | ||||
| Unknown | 5 (9.3) | 22 (2.4) | 27 (2.8) | ||||
| Cardiovascular Conditions | |||||||
| Yes | 11 (20.4) | 72 (7.9) | 83 (8.6) | <0.001 |
3.55
[1.73–7.29] |
0.787 | 1.16 [0.39–3.44] |
| No | 35 (64.8) | 814 (89.3) | 849 (87.9) | ||||
| Unknown | 8 (14.8) | 26 (2.9) | 34 (3.5) | ||||
| Cancer | |||||||
| Yes | 9 (16.7) | 47 (5.2) | 56 (5.8) | <0.001 |
4.14
[1.89–9.05] |
0.523 | 1.46 [0.46–4.66] |
| No | 39 (72.2) | 843 (92.4) | 882 (91.3) | ||||
| Unknown | 6 (11.1) | 22 (2.4) | 28 (2.9) | ||||
| Lipid Conditions | |||||||
| Yes | 7 (13.0) | 43 (4.7) | 50 (5.2) | 0.006 |
3.32
[1.41–7.82] |
0.503 | 1.49 [0.47–4.74] |
| No | 41 (75.9) | 835 (91.6) | 876 (90.7) | ||||
| Unknown | 6 (11.1) | 34 (3.7) | 40 (4.1) | ||||
| Hepatic Conditions | |||||||
| Yes | 6 (11.1) | 35 (3.8) | 41 (4.2) | 0.009 |
3.41
[1.36–8.54] |
0.259 | 2.03 [0.59–6.93] |
| Viral Hepatitis | 1 (1.9) | 8 (0.9) | 9 (0.9) | ||||
| No | 43 (79.6) | 855 (93.8) | 898 (93.0) | ||||
| Unknown | 5 (9.3) | 22 (2.4) | 27 (2.8) | ||||
| Blood Conditions | |||||||
| Yes | 5 (9.3) | 91 (10.0) | 96 (9.9) | 0.927 | 1.05 [0.40–2.71] |
0.471 | 0.53 [0.09–2.97] |
| Iron Disorders | 4 (7.4) | 69 (7.6) | 73 (7.6) | ||||
| Blood Cancer | 0 (0.0) | 6 (0.7) | 6 (0.6) | ||||
| Blood Autoimmune Disorders | 0 (0.0) | 3 (0.3) | 3 (0.3) | ||||
| No | 42 (77.8) | 799 (87.6) | 841 (87.1) | ||||
| Unknown | 7 (13.0) | 22 (2.4) | 29 (3.0) | ||||
| Gastrointestinal Conditions | |||||||
| Yes | 5 (9.3) | 137 (15.0) | 142 (14.7) | 0.326 | 0.62 [0.24–1.60] |
0.837 | 0.89 [0.31–2.59] |
| Gastrointestinal Autoimmune Disorders | 1 (1.9) | 17 (1.9) | 18 (1.9) | ||||
| Gastrointestinal Cancer | 1 (1.9) | 9 (1.0) | 10 (1.0) | ||||
| No | 44 (81.5) | 752 (82.5) | 796 (82.4) | ||||
| Unknown | 5 (9.3) | 23 (2.5) | 28 (2.9) | ||||
| Pulmonary Conditions | |||||||
| Yes | 4 (7.4) | 91 (10.0) | 95 (9.8) | 0.762 | 0.85 [0.30–2.43] |
0.883 | 1.10 [0.32–3.81] |
| No | 41 (75.9) | 793 (87.0) | 834 (86.3) | ||||
| Unknown | 9 (16.7) | 28 (3.1) | 37 (3.8) | ||||
| Autoimmune Conditions | |||||||
| Yes | 4 (7.4) | 60 (6.6) | 64 (6.6) | 0.706 | 1.23 [0.43–3.52] |
0.264 | 2.15 [0.56–8.23] |
| No | 45 (83.3) | 827 (90.7) | 872 (90.3) | ||||
| Unknown | 5 (9.3) | 25 (2.7) | 30 (3.1) | ||||
| Neurologic/Psychiatric Conditions | |||||||
| Yes | 3 (5.6) | 64 (7.0) | 67 (6.9) | 0.853 | 0.89 [0.27–2.96] |
0.834 | 1.18 [0.25–5.66] |
| Neurological Autoimmune Disorders | 1 (1.9) | 0 (0.0) | 1 (0.1) | ||||
| No | 43 (79.6) | 819 (89.8) | 862 (89.2) | ||||
| Unknown | 8 (14.8) | 29 (3.2) | 37 (3.8) | ||||
| Renal Conditions | |||||||
| Yes | 3 (5.6) | 19 (2.1) | 22 (2.3) | 0.085 | 3.00 [0.86–10.52] |
N/A | N/A |
| Renal Cancer | 1 (1.9) | 0 (0.0) | 1 (0.1) | ||||
| Renal Autoimmune Disorders | 0 (0.0) | 2 (0.2) | 2 (0.2) | ||||
| No | 46 (85.2) | 875 (95.9) | 921 (95.3) | ||||
| Unknown | 5 (9.3) | 18 (2.0) | 23 (2.4) | ||||
| Non-SARS-CoV-2 Viral Infections | |||||||
| Yes | 1 (1.9) | 33 (3.6) | 34 (3.5) | 0.559 | 0.55 [0.07–4.10] |
0.697 | 0.64 [0.07–6.04] |
| No | 47 (87.0) | 852 (93.4) | 899 (93.1) | ||||
| Unknown | 6 (11.1) | 27 (3.0) | 33 (3.4) | ||||
| Hereditary Genetic Conditions | |||||||
| Yes | 0 (0.0) | 14 (1.5) | 14 (1.4) | N/A | N/A | N/A | N/A |
| Hereditary Blood Disorders | 0 (0.0) | 8 (0.9) | 8 (0.8) | ||||
| Hereditary Lipid Disorders | 0 (0.0) | 1 (0.1) | 1 (0.1) | ||||
| No | 50 (92.6) | 879 (96.4) | 929 (96.2) | ||||
| Unknown | 4 (7.4) | 19 (2.1) | 23 (2.4) | ||||
| Other Conditions | |||||||
| Yes | 13 (24.1) | 91 (10.0) | 104 (10.8) | ||||
| Sleep Disorders | 5 (9.3) | 34 (3.7) | 39 (4.0) | ||||
| Muscle/Joint Conditions | 4 (7.4) | 21 (2.3) | 25 (2.6) | ||||
| Gynecological/Urological Conditions | 4 (7.4) | 14 (1.5) | 18 (1.9) | ||||
| Dermatological Conditions | 1 (1.9) | 12 (1.3) | 13 (1.3) | ||||
| Bone Conditions | 0 (0.0) | 9 (1.0) | 9 (0.9) | ||||
| Ophthalmologic Conditions | 0 (0.0) | 8 (0.9) | 8 (0.8) | ||||
| No | 41 (75.9) | 821 (90.0) | 862 (89.2) | ||||