Table 5.
NS1 mutation mapping for the recently sequenced DENV-4 genotype II in comparison with reference sequences.
| Sample ID | Country | Case Presentation |
Collection Year | NS1 Mutations | Clade | ||
|---|---|---|---|---|---|---|---|
| His50Tyr | Pro144Ser | ||||||
| 1 | *OP600497 | Malaysia | DF without WS | 2020 | ● | ● | 1 |
| 2 | *OP600506 | Malaysia | DF with WS | 2020 | 2 | ||
| 3 | *OP600478 | Malaysia | DF with WS | 2020 | 2 | ||
| 4 | *OP600495 | Malaysia | DF with WS | 2020 | ● | 1 | |
| 5 | *OP600507 | Malaysia | DF with WS | 2020 | 2 | ||
| 6 | *OP600496 | Malaysia | Severe Dengue | 2021 | 2 | ||
| 7 | *OP600508 | Malaysia | Severe Dengue | 2021 | ● | ● | 1 |
| 8 | *OP600498 | Malaysia | Severe Dengue | 2021 | ● | ● | 1 |
| 9 | *OP600499 | Malaysia | DF with WS | 2022 | ● | ● | 1 |
| 10 | *OP600509 | Malaysia | Severe Dengue | 2022 | ● | 2 | |
| 11 | *OP600510 | Malaysia | DF with WS | 2022 | ● | ● | 1 |
| 12 | *OP600511 | Malaysia | DF without WS | 2022 | ● | ● | 1 |
| 13 | *OP600512 | Malaysia | DF with WS | 2022 | ● | 1 | |
| 14 | *OP604360 | Malaysia | DF with WS | 2022 | ● | ● | 1 |
| 15 | MH888334.1 | Malaysia | NA | 2013 | |||
| 16 | MH051734.1 | Malaysia | NA | 2014 | |||
| 17 | JX024757.1 | Singapore | NA | 2010 | |||
| 18 | MW301595.1 | Malaysia | NA | 2013 | |||
| 19 | KC762695.1 | Indonesia | NA | 2007 | |||
| 20 | MH823210.1 | Indonesia | NA | 2014 | |||
| 21 | MH382789.1 | Papua NG | NA | 2016 | |||
| 22 | KJ579245.1 | Brazil | NA | 2012 | |||
| 23 | KY474335.1 | Ecuador | NA | 2014 | |||
DF = Dengue fever, WS = Warning sign, NA = Data not available, * = Samples sequenced in this study, • = mutation detected.