Table 6.
Quality assessment of the predicted WT and mutant DENV-4 NS1 structures using SWISS-MODEL and AlphaFold2.
| Program | WT/ Mutation |
Procheck (Ramachandran Plot Statistic (%)) |
ProSA | Errat (%) | |||
|---|---|---|---|---|---|---|---|
| Most Favoured |
Additionally Allowed | Generously Allowed | Disallowed | Z-Score | Overall Quality Factor Score | ||
| SWISS-MODEL | WT | 85.6 | 13.1 | 0.5 | 0.8 | −6.67 | 91.2442 |
| p.His50Tyr | 87.1 | 11.7 | 0.7 | 0.5 | −6.7 | 88.2083 | |
| p.Pro144Ser | 87.1 | 11.7 | 0.7 | 0.5 | −6.71 | 88.2083 | |
| AlphaFold2 | WT | 90.4 | 9.3 | 0 | 0.3 | −6.95 | 87.1681 |
| p.His50Tyr | 90.4 | 9.3 | 0 | 0.3 | −7 | 86.9822 | |
| p.Pro144Ser | 90.4 | 9.2 | 0 | 0.3 | −7.04 | 87.1681 | |