Table A5.
Comparison of neutralizing antibody GMC levels in different the subgroup populations.
| Population | Blood Sampling Time | Analysis Set | T5 | C5 | T4 | C4 | Between T5s | Between T4s | Between T4 and T5s | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | GMC (95% CI) | N | GMC (95% CI) | N | GMC (95% CI) | N | GMC (95% CI) | Ratio (95% CI) | P | Ratio (95% CI) | P | Ratio (95% CI) | P | |||
| Total population | 7 days after the first dose of vaccine | PPS1 | 324 | 0.48 (0.41,0.55) | 316 | 0.30 (0.26, 0.35) | 321 | 0.85 (0.73, 0.99) | 323 | 0.43 (0.37, 0.50) | 1.58 (1.29, 1.94) | <0.0001 | 1.97 (1.58, 2.47) | <0.0001 | 1.78 (1.43, 2.20) | <0.0001 |
| 14 days after the first dose of vaccine | PPS2 | 329 | 33.04 (30.04, 36.34) | 329 | 30.86 (28.13, 33.86) | 333 | 32.67 (29.71, 35.92) | 331 | 30.99 (28.21, 34.03) | 1.07 (0.94, 1.22) | 0.3142 | 1.05 (0.92, 1.20) | 0.4364 | 0.99 (0.86, 1.13) | 0.8691 | |
| 14 days after the full course of immunization | PPS3 | 659 | 14.45 (13.56, 15.41) | 643 | 15.51 (14.54, 16.54) | 653 | 15.37 (14.34, 16.48) | 663 | 15.42 (14.44, 16.46) | 0.93 (0.85, 1.02) | 0.1263 | 1.00 (0.91, 1.10) | 0.9514 | 1.06 (0.97, 1.17) | 0.1982 | |
| Pre-immunization antibody-positive population | 7 days after the first dose of vaccine | PPS1 | 22 | 4.99 (2.44, 10.21) | 29 | 2.42 (1.52, 3.85) | 29 | 7.48 (4.04, 13.85) | 22 | 7.76 (3.59, 16.78) | 2.07 (0.93, 4.59) | 0.0739 | 0.96 (0.37, 2.49) | 0.9383 | 1.50 (0.60, 3.75) | 0.3801 |
| 14 days after the first dose of vaccine | PPS2 | 36 | 39.69 (28.48, 55.31) | 32 | 34.77 (25.24, 47.89) | 39 | 50.36 (34.30, 73.94) | 44 | 41.49 (30.70, 56.07) | 1.14 (0.72, 1.80) | 0.5635 | 1.21 (0.75, 1.95) | 0.4197 | 1.27 (0.77, 2.10) | 0.3485 | |
| 14 days after the full course of immunization | PPS3 | 56 | 20.84 (15.96, 27.22) | 62 | 21.45 (17.22, 26.71) | 70 | 24.54 (18.66, 32.26) | 66 | 27.16 (20.17, 36.58) | 0.97 (0.69, 1.36) | 0.8678 | 0.90 (0.61, 1.35) | 0.6164 | 1.18 (0.80, 1.73) | 0.4022 | |
| 10–18 years | 7 days after the first dose of vaccine | PPS1 | 19 | 1.17 (0.62, 2.21) | 14 | 0.37 (0.21, 0.63) | 18 | 1.33 (0.82, 2.17) | 18 | 1.02 (0.51, 2.04) | 3.20 (1.38, 7.40) | 0.0083 | 1.31 (0.58, 2.97) | 0.5076 | 1.14 (0.52, 2.48) | 0.7398 |
| 14 days after the first dose of vaccine | PPS2 | 25 | 44.10 (30.62, 63.51) | 37 | 63.07 (48.08, 82.73) | 31 | 53.75 (39.57, 73.02) | 26 | 53.35 (39.48, 72.11) | 0.70 (0.45, 1.08) | 0.1061 | 1.01 (0.66, 1.54) | 0.9719 | 1.22 (0.77, 1.93) | 0.3940 | |
| 14 days after the full course of immunization | PPS3 | 44 | 23.33 (18.49, 29.44) | 51 | 24.28 (20.99, 28.08) | 50 | 26.99 (21.64, 33.65) | 45 | 24.33 (19.06, 31.06) | 0.96 (0.74, 1.25) | 0.7637 | 1.11 (0.80, 1.53) | 0.5275 | 1.16 (0.84, 1.59) | 0.3631 | |
| ≥18 years | 7 days after the first dose of vaccine | PPS1 | 305 | 0.45 (0.39, 0.52) | 302 | 0.30 (0.26, 0.35) | 303 | 0.83 (0.70, 0.97) | 305 | 0.41 (0.35, 0.48) | 1.51 (1.23, 1.86) | 0.0001 | 2.02 (1.61, 2.55) | <0.0001 | 1.83 (1.47, 2.28) | <0.0001 |
| 14 days after the first dose of vaccine | PPS2 | 304 | 32.26 (29.23, 35.61) | 292 | 28.19 (25.66, 30.97) | 302 | 31.04 (28.12, 34.26) | 305 | 29.58 (26.84, 32.60) | 1.14 (1.00, 1.31) | 0.0526 | 1.05 (0.91, 1.20) | 0.4949 | 0.96 (0.84, 1.11) | 0.5862 | |
| 14 days after the full course of immunization | PPS3 | 615 | 13.97 (13.08, 14.91) | 592 | 14.92 (13.94, 15.97) | 603 | 14.67 (13.66, 15.77) | 618 | 14.92 (13.95, 15.96) | 0.94 (0.85, 1.03) | 0.1685 | 0.98 (0.89, 1.09) | 0.7436 | 1.05 (0.95, 1.16) | 0.3186 | |