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. 2023 Aug 10;15(16):3527. doi: 10.3390/nu15163527

Figure 4.

Figure 4

Inhibitory profiles of transporter-substrates/inhibitors on MCT13-mediated cephradine uptake. Uptake of cephradine was measured at 1000 μM in KCl buffer for 5 min, using HEK293T cells expressing MCT13 and/or CD147. The substrates/inhibitors of transporters were used at 10 mM except for cyclosporine A (CysA) and rifampicin at 50 μM. MCT13-mediated uptake was calculated by subtracting the uptake amount of mock-transfected cells from that of MCT13-transfected cells. Each bar represents the mean ± S.D. (n = 6), except for the control (n = 15), control (1% DMSO) (n = 9), and probenecid (n = 3). The small sample number in the case of probenecid was due to several measurements that were below the detection limit and did not appear in the graph. CysA and rifampicin were used in KCl buffer containing DMSO at a final concentration of 1%(v/v). ** p < 0.01, compared with the corresponding control by one-way ANOVA with Dunnett’s multiple comparisons test.